BIPs 2010

Bridge 2 Industry Projects Approved in 2010:

Title: Development and Application of CHIP-LC-MS Technology for Systems Biology Research
Applicant: Dr. Bernd Wollscheid (ETHZ)
Industry Partner: Dr. John Fjeldsted, Agilent Technologies 
Scientific Fields/Keywords:

  • Strategic Partnership
  • CHIP-LC-MS technology development
  • Systems Biology
  • Proteomics

Title: Systems-level Analysis of Ras-driven Tumor Metabolism Across Growth Conditions – 2D Plastic to 3D to Xenografts to Tumors
Applicant: Prof. Uwe Sauer (ETHZ)
Industry Partner: Dr. Edward Drigger, Agios Pharmaceuticals
Scientific Fields/Keywords: 

  • Oncology
  • Metabolomics
  • In vitro/in vivo cancer models
  • Ras tumors metabotyping

Title: Development of a High Precision Cellular Nanoinjection Technology: a Demonstration with HeLa Cells
Applicants: Dr. Tomaso Zambelli (ETHZ), Prof. Julia Vorholt (ETHZ)
Industry Partner: Dr. Michael Gabi, Cytosurge LLC
Scientific Fields/Keywords:

  • Nanobiotechnology
  • Single-cell injection
  • Metabolites
  • Microengineering
  • Nanofluidics

Title: Simulation and Visualization of Crowding and Combinatorial Signaling
Applicant: Prof. Heinz Koeppl (ETHZ)
Industry Partner: Dr. Pablo de Heras Ciechomski, ScienceVisuals Sarl
Scientific Fields/Keywords:

  • Stochastic processes
  • Computational systems biology
  • Spatial simulation
  • Computer graphics
  • Virtual reality

Title: High Resolution Mass Spectrometry for Simultaneous Qualitative and Quantitative Analysis of Xenobiotic and Endogenous Metabolites
Applicant: Prof. Gérard Hopfgartner (UniGE)
Industry Partner: Dr. Ron Bonner, AB Sciex
Scientific Fields/Keywords:

  • Analytical Chemistry
  • High resolution mass spectrometry
  • MS acquisition workflow
  • Metabolism
  • Metabolomics
  • MS data mining

Title: Identification of Synaptic Core Pathways as Targets for Autism Treatment
Applicant: Prof. Peter Scheiffele (UniBS)
Industry Partner: Dr. Will Spooren, Hoffmann - La Roche
Scientific Fields/Keywords:

  • Neuroscience
  • Autism
  • Synapse
  • Mouse models
  • Pharmacological treatment
  • Neural development

Title: High Content Screening by Digital Holographic Imaging
Applicants: Dr. Gerardo Turcatti (EPFL), Dr. Pierre Marquet (EPFL)
Industry Partner: Dr. Yves Emery, Lyncée tec SA
Scientific Fields/Keywords:

  • Digital Holographic Microscopy (DHM)
  • High Content Screening (HCS)
  • Toxicity assays
  • Cell Viability
  • Chemical interference siRNA
  • Gene knockdown

Title: Development of Kinetic Models of RNA-dependent Silencing
Applicant: Prof. Mihaela Zavolan (UniBS)
Industry Partner: Dr. Nicole Meisner, Novartis Institutes for Biomedical Research
Scientific Fields/Keywords:

  • Computational modeling
  • RNAi
  • miRNA
  • siRNA
  • Gene silencing
  • Kinetic model

Title: Gene Co-regulation Network Inference and Visualization Based on Novel Bicluster Maps
Applicant: Prof. Wilhelm Gruissem (ETHZ)
Industry Partner: Dr. Stefan Bleuler, Nebion AG
Scientific Fields/Keywords:

  • Bioinformatics
  • Biclustering
  • Gene expression regulation networks
  • Transcriptome analysis

Contact

Dr. Eavan Dorcey
Managing Director SystemsX.ch
Clausiusstr. 45, CLP D 7
CH - 8092 Zurich
phone +41 44 632 74 23
fax +41 44 632 15 64
eavan.dorcey(at)systemsx.ch