1. A computational high-throughput platform for characterizing transcription
      regulatory interactions
      Co-applicant: Matteo Dal Peraro (EPFL), Sebastian Maerkl (EPFL)
      Scientific fields/keywords: transcription factor, protein-DNA interactions, molecular
      simulation, multiscale modeling, high-performance computing, binding, affinity, MITOMI, gene regulatory network, free energy calculation

    2. Exploration of Chemistry to Map Proteome/Pharmacome Interactions
      Co-applicant: Matthias Wymann (UniBS), Bernd Giese (UniBS)
      Keywords: Chemistry, Pharmacology, Biochemistry, Proteomics, Cell Biology; Drug development, protein arrays, small molecular antibodies, combinatorial chemistry, chemical biology

    3. High-Throughput Proteomic Screens using Matrix-Assisted Laser
      Desorption/Ionization Multiple Reaction Monitoring (MALDI -MRM)
      Co-applicant: Gerard Hopfgartner (UniGE/UniL), Bruno Domon (ETHZ)
      Keywords: Analytical Chemistry, High-Throughput SB, Quantitative Proteomics, Mass Spec, Model Organism

    4. How to bridge the sequence to function gap: application to uncharacterized
      human proteins
      Co-applicant: Amos Bairoch (SIB/UniGE), Marco Pagni (SIB)
      Keywords: Bioinformatics; Data analysis, Data modeling, Sequence Analysis, Data mining

    5. Quantitative analysis and prediction of protein glycation
      Co-applicant: J.-C. Sanchez (UniGE), F. Lisacek (SIB-SIB)
      Keywords: Biomedical proteomics; Post-translational modifications, glycation, Mass spectrometry, Diabetes, glycohemoglobin, proteomics

    6. Realtime metabolic biosensors
      Co-applicant: N. Zamboni (ETHZ), Matthias Peter (ETHZ)
      Keywords: Quantitative biology, fluorescence microscopy, biosensor,
      FRET, mass spectrometry, flux analysis, metabolomics

    7. RootoX: A systems approach to understand how herbivores cope with root-produced toxins
      Co-applicant: Ted Turlings (UniNE), J.-L.Wolfender (UniGE)
      Keywords: Insect metabolomics, detoxification processes, plant-insect interactions, Diabrotica virgifera,

    8. Technology Development for High Throughput siRNA-Based Genetic
      Screens in Mammalian Cells
      Co-applicant: Thanos Halazonetis (UniGE), Juergen Brugger (EPFL)
      Keywords: Engineering Sciences and Technologies; siRNA Arrays, Gold Nanopatterns, Tissue Culture, Surface Coating, Live Cell Microscopy, Immunofluorescence, Image Analysis