1. A system’s level analysis of the spatio-temporal regulation of signaling during polarized cell migration

    Co-applicants: Dagmar Iber (ETHZ), Olivier Pertz (UniBS)
    Scientific Field/keywords: cell migration, proteomics, signaling, systems biology, modeling

  2. An integrative approach to study adipocyte extracellular signaling events
    linked to the development of metabolic disorders
    Co-applicants: Christian Wolfrum (ETHZ), Bernd Wollscheid (ETHZ)
    keywords:Adipocyte, Obesity, Diabetes, Surface Proteom, Mass Spectrometry

  3. Developing and Testing a Mathematical Model for Cell Specification in the Embryo Sac of Arabidopsis thaliana
    Co-applicants: Ueli Grossniklaus (UZH), Barbara Hellriegel (UZH), Bruno Müller (UZH)
    Keywords:pattern fromation, cytokinin signaling, gametophyte development, mathematical modeling, gradients

  4. Genetic and epigenetic diversity of tumors: A combined deep sequencing
    and mathematical modeling approach to the somatic evolution of cancer
    Co-applicants: Niko Beerenwinkel (ETHZ) Christian Beisel (ETHZ) Holger Moch (UZH)
    Keywords: Genetics, Information Sciences, Medicine, Engineering Sciences; deep sequencing, cancer, evolutionary dynamics, carcinogenesis, tumorigenesis, haplotype inference, DNA methylation

  5. Genome-wide prediction of coactivator-controlled transcriptional networks
    using data from ultrahigh-throughput sequencing technologies
    Co-applicants: Christoph Handschin (UniBS), Eric van Nimwegen (UniBS)
    Keywords: transcriptional regulation, bioinformatics, coactivators, PGC-1alpha regulatory site prediction, massively parallel sequencing

  6. Genomic analysis of information transfer along the DNA by transcriptional
    interference
    Co-applicants: Attila Becskei (UZH), Erwin Bolthausen (UZH)
    Keywords: Mathematics, Genetics, Saccharomyces cerevisiae, stochastic, gene network

  7. Genomic and physical constraints that regulate cellular shape
    Co-applicants: Rafael Carazo Salas (ETHZ) Gabor Székely (ETHZ)
    Keywords: Life Sciences, Mathematics; cell shape, cell polarity, genomic, gene knock-out, high-content microscopy, high- throughput microscopy, image processing, morphological profiling

  8. Microelectronics and genetics to study retinal neuronal circuit dynamics
    Co-applicants: Andreas Hierlemann (ETHZ), Botond Rosta (FMI)
    Keywords: Retina, Electrophysiology, Microelectronics, Genetic interventions, Neuronal cells and circuits

  9. Predicting functional redundancy in protein networks
    Co-applicants: Niko Beerenwinkel (ETHZ), Gunter Mendes (ETHZ)
    Keywords: Life Sciences, Mathematics, Molecular bio; RNA interference, redundancy, network reliability, protein- protein interaction

  10. Proteomic analyses of post-translational modifications
    Co-applicants: Isabelle Mansuy (ETHZ) Ivo Sbalzarini (ETHZ)
    Keywords: Engineering, Medicine, Mathematics; proteomics, brain, histone, modelling

  11. Quantitative analysis and mathematical modeling of polarity establishment
    in C.elegans embryos
    Co-applicants: Pierre Gönczy (EPFL) Felix Naef (EPFL)
    Keywords: Cell polarity, C. elegans, Quantitative analysis, Mathematical modeling

  12. Time-resolved luminescence imaging of cells and tissue in a Lab-on-a-Chip
    using lanthanide-doped nanoparticle labels for breast cancer detection
    Co-applicants: Martin Gijs (EPFL) Hans-Anton Lehr (Unil) Jean-Claude Bünzli (EPFL)
    Keywords: (bio)chemistry, micro-engineering, cell biology, cancer
    diagnosis