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Tuberkulose-Erreger suchen sich ihre ökologische Nische
Tuberkulose-Erreger können sich spezifisch in ihre ökologische Nische einpassen: Generalisten verbreiten sich weltweit, Spezialisten finden sich nur in bestimmten Weltregionen. Dies könnte die Entwicklung künftiger Impfstoffe weiter erschweren. Zu diesem Schluss kommen Forschende des Schweizerischen Tropen- und Public Health-Instituts und der Universität Basel aufgrund einer genetischen Analyse von Tuberkulose-Erregern aus über hundert Ländern.
Diese Forschungsarbeit wurde von SystemsX.ch unterstützt (RTD-Projekt TbX).
weiter zum Artikel, erschienen in den Uni News der Universität Basel »
X-Letter 33
The X-Letter 33 has been published. In this issue of the SystemsX.ch print magazine, we highlight the central role that technology plays in systems biology research.
Read the X-Letter 33 and/or subscribe to the print magazine »
Super-resolution imaging of multiple cells
Single-molecule localization microscopy (SMLM) techniques have been established as important tools for the study of cellular features with resolutions of the order of 10 nm. However, these techniques are limited by a highly constrained field of view (FOV) as well as field-dependent image resolution. Researchers from the EPF Lausanne have developed a low cost microlens array (MLA)-based epi-illumination system—flat illumination for field-independent imaging (FIFI)—that can efficiently and homogeneously perform simultaneous imaging of multiple cells with nanoscale resolution. This research was supported by a SystemsX.ch Transition Postdoc Fellowship. More information on Nature online»
Broadly neutralizing HIV antibodies pave the way for vaccine
A small number of people infected with HIV produce antibodies with an amazing effect: Not only are the antibodies directed against the own virus strain, but also against different sub-types of HIV that circulate worldwide. Researchers from the University of Zurich and University Hospital Zurich now reveal which factors are responsible for the human body forming such broadly neutralizing HIV antibodies, thereby opening new avenues for the development of an HIV vaccine (Image: David S. Goodsell, RCSB PDB).This research was supported by the SystemsX.ch RTD Project AntibodyX.
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